The Holy of Holies (Biblical Hebrew: קֹדֶשׁ הַקֳּדָשִׁים, romanized: Qoḏeš haq-Qŏḏāšim) or Devir (הַדְּבִיר had-Dəḇir 'the Sanctuary') is a term in the Hebrew Bible that refers to the inner sanctuary of the Tabernacle, where the Shekhinah (God's presence) appeared. According to Hebrew tradition, the area was defined by four pillars that held up the veil of the covering, under which the Ark of the Covenant was held above the floor. According to the Hebrew Bible, the Ark contained the Ten Commandments, which were given by God to Moses on Mount Sinai. The first Temple in Jerusalem, called Solomon's Temple, was said to have been built by King Solomon to keep the Ark.

Jewish traditions viewed the Holy of Holies as the spiritual junction of the Seven Heavens and Earth, the "axis mundi".

As a part of the Temple in Jerusalem, the Holy of Holies was situated somewhere on Temple Mount; its precise location is a matter of dispute, with some classical Jewish sources identifying its location with the Foundation Stone, which sits under the current Dome of the Rock.^[1][2] Other Jewish scholars argue that contemporary reports would place the Temple to the north or east of the Dome of the Rock.^[3]

The Crusaders associated the Holy of Holies with the Well of Souls, a small cave that lies underneath the Foundation Stone in the Dome of the Rock.^[4]